Monday, June 21, 2010
60+ Facts
Saturday, June 19, 2010
Gene Therapy Hope for HIV: Engineered Stem Cells Hold Promise
Gene Therapy Hope for HIV: Engineered Stem Cells Hold Promise
When it comes to research on HIV and AIDS treatments, it can be hard to know when to celebrate a small advance–everyone wants to see progress, but so many experimental avenues that seemed promising have turned out to be dead ends. Still, a new study that tried a sophisticated form of gene therapy as an HIV treatment seems cause for cautious optimism. If it bears out under further testing, the technique could lead to a one-shot, long-lasting treatment that could replace the punishing regimen of daily medications.
Treating HIV currently comes down to controlling the viral load with a mixture antiretroviral drugs, but over time, this drug cocktail becomes less effective. Researcher John Rossi and his colleagues tried to craft a more permanent treatment by genetically modifying the HIV-infected patients’ own blood stem cells and increasing the cells’ ability to fight off the virus. The researchers weren’t able to truly combat the virus in this experiment–the patients’ viral loads remained the same–but their work moved beyond previous attempts in two ways: They successfully modified blood stem cells by giving them anti-HIV genes, and those cells survived for two years in patients.Earlier clinical studies the group conducted with the same strategy made little headway, but now the researchers have overcome two key obstacles, says Rossi, a molecular geneticist. One is that they managed to stitch the anti-HIV genes into a high percentage of the appropriate stem cells. The other is that the cells lived for a long time. “If we could increase the number of modified cells by 10- or 100-fold, we might be able to stop the virus itself,” says Rossi. [ScienceNow]The small study published in Science Translational Medicine tested the safety of the technique for HIV-infected patients, and served as a proof of concept. The four patients in this study were undergoing therapy for AIDS-related lymphoma at City of Hope cancer center in California. Part of the usual treatment for this condition is to remove blood stem cells (found in bone marrow) before cell-damaging chemotherapy, and to then return them after treatment. Researchers wanted to test their virus-fighting cells’ survival skills, so with each patient’s normal blood stem cells, the researchers also reintroduced a small number of modified cells.
They modified the cells in three ways: They boarded up the cells’ doors to keep the HIV virus out, and made two genetic changes to the cells’ internal defenses so that the virus would have a harder time copying itself if it made it through.
“That’s a major finding,” Rossi added. While the number of cells expressing those genes was too low to provide any therapeutic benefit, it’s “proof of principle” that gene therapy may provide long-term HIV treatment, he said. [The Scientist]As a next step, researchers hope to implant a greater number of modified cells in patients, to see how well they can fight and how long their defenses hold.
Zero-Energy Fridge Uses Gel to Preserve Food
Zero-Energy Fridge Uses Gel to Preserve Food
The Bio Robot Refrigerator was designed by Yuriy Dmitriev and is currently a semifinalist in Electrolux's Design Lab competition. The Bio Robot has no motor, compressor or other electrical components, but it does contain a green biopolymer gel that uses luminescence to preserve food.
To store food, you press the item into the gel, which then envelopes it, creating a "separate capsule" for each product.
The designer highlights its benefits as being: zero-energy and silent operation, four times smaller than a traditional fridge, but maximized storage space and the absence of doors allows horizontal or vertical placement and displays food in plain view.
I'm not sure how you'd go about cleaning this refrigerator, or how it'd handle storing, say, a pot of soup, but any zero-energy concept is OK by me.
via EcoFriend
2013 Solar Storm Expected To Cause Trouble
(Telegraph) - National power grids could overheat and air travel severely disrupted while electronic items, navigation devices and major satellites could stop working after the Sun reaches its maximum power in a few years.
Senior space agency scientists believe the Earth will be hit with unprecedented levels of magnetic energy from solar flares after the Sun wakes “from a deep slumber” sometime around 2013, The Daily Telegraph can disclose.
In a new warning, Nasa said the super storm would hit like “a bolt of lightning” and could cause catastrophic consequences for the world’s health, emergency services and national security unless precautions are taken.
Scientists believe it could damage everything from emergency services’ systems, hospital equipment, banking systems and air traffic control devices, through to “everyday” items such as home computers, iPods and Sat Navs.
Due to humans’ heavy reliance on electronic devices, which are sensitive to magnetic energy, the storm could leave a multi-billion pound damage bill and “potentially devastating” problems for governments.
“We know it is coming but we don’t know how bad it is going to be,” Dr Richard Fisher, the director of Nasa's Heliophysics division, said in an interview with The Daily Telegraph....
read full story here
NASA: Moon may have more water than the Great Lakes
NASA: Moon may have more water than the Great Lakes
The fight to keep Great Lakes water in the Great Lakes isn’t just regional anymore. Things just got global, if not interplanetary.
That’s because new NASA-funded research suggests that the amount of water locked up in Earth’s longtime orbital nemesis — the moon — could exceed the volume of the Great Lakes.
So unless the region conserves every drop it can, I’ll have to listen to my grandkids prattle on about how “The Great Lakes were cool until their volume was marginalized by the discovery of hydroxyl indigenous to lunar apatite, a water-bearing mineral.”
For over 40 years we thought the moon was dry,” said Francis McCubbin of Carnegie and lead author of the report published in Monday’s Online Early Edition of the Proceedings of the National Academy of Sciences. “In our study we looked at hydroxyl, a compound with an oxygen atom bound with hydrogen, and apatite, a water-bearing mineral in the assemblage of minerals we examined in two Apollo samples and a lunar meteorite.
Planes Punch Holes in Clouds and Create Rain
Look up in the sky near an airport and you might see some unusual cloud formations. The one on the left is called a “hole-punch,” and meteorologists have been speculating on the cause. They suggested that the holes may have been the result of shock waves from jets or warming of the air by jets.
Researchers from the National Center for Atmospheric Research and elsewhere now say that the odd-shaped clouds can be caused by either turboprop or jet aircraft as they pass through a particular type of cloud layer. Their study appears in the Bulletin of the American Meteorological Society.
On average, about 7.8 percent of the Earth is covered by midlevel liquid-layer topped stratiform clouds (those are the ones that look like a flat layer of cloud). The liquid is super-cooled, at a temperature below freezing but still in liquid form. When a plane passes nearby, pressure changes from the spinning turboprop or air passing over wings can cool the liquid even further, turning it into ice. That ice becomes the “seed” for precipitation. More water droplets condense and freeze on these seeds, forming snow. If the air below is warm enough, if melts into rain. The same process is also responsible for canal clouds, which are just a long and thin versions of the hole-punch.
The cloud layer needed for this phenomenon is especially common in the Pacific Northwest and western Europe. I’m off to Seattle this weekend; I think I’ll have to check out the skies. (HT: Greg Laden)
NASA Discovers 300 Planets outside Solar system
The observations have been made from Kepler orbiting telescope, which was placed in the orbit in March, last year. The spacecraft has identified the indications of a planet crossing nearly 700 stars.
The lead author of the current study, William Borucki, said that the existence of the planets has not been given any approval from other scientists, as there are rooms for mistakes in identifying them.
In order to confirm, more detailed studies are to be conducted by the team. Kepler has been noting the intensity of as many as 156,097 stars in Cygnus and Lyra. They are trying to identifying any reduction in their brightness due to the presence of any planet in front of them.
The planets discovered in the current study have been termed as `candidate planets'.
The report was compiled on May 25 and presented on June 14. Kepler researchers observed the stars and the spotted planets for nearly 33.5 days.
The team observed as many as 12,000 stars losing brightness with the progress in their motion.
The future of summer: Air conditioners that are 90 percent more efficient
Air conditioners are a pain. They use an incredible amount of energy, reflected in incredibly high electricity bills in the summer months. But in some places, like Texas and Arizona, it’s hard to go without them. Now, the National Renewable Energy Laboratory may have an answer to the problem: A brand new air conditioning design that could make AC units 90 percent more efficient than they are today.
This is not just a new spin on the traditional design. NREL has ditched major components of today’s AC units, including their condensers and compressors. It generates colder air by evaporating water off a wet surface with a built-in fan. There is a desiccant included to make sure the air is dry.
In addition to slashing the amount of energy needed to run a typical AC unit, the NREL model, called the DEVap, also eliminates the need for chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs), toxic chemicals used in many of today’s air conditioners that pollute the atmosphere.
Previously, this evaporative air conditioning process only worked in dry, hot climates, because the cool air generated would otherwise contain too much moisture. The addition of the desiccants has made it functional in a range of climates, even very humid environments, NREL says.
The challenge now will be to make the NREL air conditioner cost competitive with those already on the market. It might be as many as five summers before consumers can get buy the units to cool their houses, the laboratory says. It will be licensing the deign for commercial distribution.
Steeply reducing the amount of energy sucked by air conditioners could have a major impact on overall energy use in the U.S. and abroad. After all, air conditioners account for 5 percent of energy used in the U.S. every year.
Seventh Graders Find a Cave on Mars
Seventh Graders Find a Cave on Mars
June 17, 2010Enlarge
Sixteen seventh-grade students at Evergreen Middle School in Cottonwood, Calif., found the Martian pit feature at the center of the superimposed red square in this image while participating in a program that enables students to use the camera on NASA's Mars Odyssey orbiter. Image Credit: NASA/JPL-Caltech/ASU
They went looking for lava tubes on Mars -- and found what may be a hole in the roof of a Martian cave.
The 16 students in Dennis Mitchell's 7th-grade science class at Evergreen Middle School in Cottonwood, California, chose to study lava tubes, a common volcanic feature on Earth and Mars. It was their class project for the Mars Student Imaging Program (MSIP), a component of ASU's Mars Education Program, which is run out of the Mars Space Flight Facility on the Tempe campus.
The imaging program involves upper elementary to college students in Mars research by having them develop a geological question about Mars to answer. Then the students actually command a Mars-orbiting camera to take an image to answer their question. Since MSIP began in 2004, more than 50,000 students have participated to varying extents.
"The students developed a research project focused on finding the most common locations of lava tubes on Mars," says Mitchell. "Do they occur most often near the summit of a volcano, on its flanks, or the plains surrounding it?"
To answer the question, the students examined more than 200 images of Mars taken with the Thermal Emission Imaging System (THEMIS), an instrument on NASA's Mars Odyssey orbiter. Philip Christensen, a Regents' Professor of geological sciences in the School of Earth and Space Exploration, is the instrument's designer and principal investigator. The students chose for their targeted THEMIS image (plus a secondary backup image) areas on Pavonis Mons volcano that had yet to be photographed by THEMIS at highest resolution (18 meters, or 59 feet, per pixel).
On their two targeted images the students found lava tubes, as they had hoped. And on the backup image, they also found a small, round black spot. Many Martian lava tubes are marked by aligned chains of collapse pits, which typically have flat floors and sloping sides. The spot they students found, however, appears to have vertical sides.
Such features made a stir in the news in 2007, when Glen Cushing, a U.S. Geological Survey scientist, published a paper showing several Martian examples, which had been located using the heat-sensing capability of THEMIS. He argued that these holes were anomalous as compared to the usual chain pit crater, being smaller and resembling a relatively straight-sided shaft going down into the ground.
Cushing proposed that these anomalous pit craters are "skylights" — places where a small part of the roof of a cave or a lava tube has collapsed, opening the subsurface to the sky. They typically appear cooler than the ground surface by day, but warmer than it by night. This is exactly what would be expected, given that Martian surface temperatures have a large diurnal range, while subsurface temperatures hold fairly even.
"This pit is certainly new to us," Cushing told the students. "And it is only the second one known to be associated with Pavonis Mons." He estimated it to be approximately 190 by 160 meters (620 x 520 feet) wide and 115 meters (380 feet) deep at least.
In addition, he said, the spot appears clear against the background surface of Pavonis Mons. "It sticks out like a sore thumb in THEMIS predawn thermal observations."
The students have submitted their site as a candidate for imaging by the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter. HiRISE can image the surface at about 30 centimeters (12 inches) per pixel, which may allow a look inside the hole in the ground.
"The Mars Student Imaging Program is certainly one of the greatest educational programs ever developed," says Mitchell. "It gives the students a good understanding of the way research is conducted and how that research can be important for the scientific community. This has been a wonderful experience."
Human Race "Will Be Extinct Within 100 Years," Claims Leading Scientist
And now Professor Frank Fenner, emeritus professor of microbiology at the Australian National University, has predicted that the human race will be extinct within the next 100 years.
He has claimed that the human race will be unable to survive a population explosion and 'unbridled consumption.'
Fenner told The Australian newspaper that 'homo sapiens will become extinct, perhaps within 100 years.'
'A lot of other animals will, too,' he added.
'It's an irreversible situation. I think it's too late. I try not to express that because people are trying to do something, but they keep putting it off.'
Since humans entered an unofficial scientific period known as the Anthropocene - the time since industrialisation - we have had an effect on the planet that rivals any ice age or comet impact, he said.
Fenner, 95, has won awards for his work in helping eradicate the variola virus that causes smallpox and has written or co-written 22 books.
He announced the eradication of the disease to the World Health Assembly in 1980 and it is still regarded as one of the World Health Organisation's greatest achievements.
He was also heavily involved in helping to control Australia's myxomatosis problem in rabbits.
Last year official UN figures estimated that the world's population is currently 6.8 billion. It is predicted to exceed seven billion by the end of 2011.
Fenner blames the onset of climate change for the human race's imminent demise.
He said: 'We'll undergo the same fate as the people on Easter Island.
'Climate change is just at the very beginning. But we're seeing remarkable changes in the weather already.'
'The Aborigines showed that without science and the production of carbon dioxide and global warming, they could survive for 40,000 or 50,000 years.
'But the world can't. The human species is likely to go the same way as many of the species that we've seen disappear.'
'Frank may well be right, but some of us still harbour the hope that there will come about an awareness of the situation and, as a result the revolutionary changes necessary to achieve ecological sustainability.'
Simon Ross, the vice-chairman of the Optimum Population Trust, said: 'Mankind is facing real challenges including climate change, loss of bio-diversity and unprecedented growth in population.'
Professor Fenner's chilling prediction echoes recent comments by Prince Charles who last week warned of 'monumental problems' if the world's population continues to grow at such a rapid pace.
And it comes after Professor Nicholas Boyle of Cambridge University said that a 'Doomsday' moment will take place in 2014 - and will determine whether the 21st century is full of violence and poverty or will be peaceful and prosperous.
in the last 500 years there has been a cataclysmic 'Great Event' of international significance at the start of each century, he claimed.
In 2006 another esteemed academic, Professor James Lovelock, warned that the world's population may sink as low as 500 million over the next century due to global warming.
He claimed that any attempts to tackle climate change will not be able to solve the problem, merely buy us time.
Friday, June 18, 2010
facts 8
· The highest toll paid by a ship to cross the
· The name of the famous snack "Twinkies" was invented by seeing a billboard in
· The word "Nazi" is actually an abbreviation for Nationalsozialistische Deutsche Arbeiterpartei, which refers to the National Socialist German Workers Party
· The unique characteristics of Barbie dolls in
· The Coca Cola company offers more than 300 different beverages
·
· Five percent of the people who use personal ads for dating are already married
· Camel is considered unclean meat in the Bible
· Soldier Field is the oldest field in the NFL
· In the
· The name Jeep came from the abbreviation used in the army for the"General Purpose" vehicle, G.P.
· Eating eight strawberries will provide you with more Vitamin C than an orange
· The first toilet ever seen on television was on "Leave It To Beaver".
· Mosquitoes have teeth
· To be born on Sunday was considered a sign of great sin during the Puritan times
· The citrus soda "7 UP" was created in 1929. The original name of the popular drink was "Bib-Label Lithiated Lemon-Lime Soda", but it got changed to "7 UP."
· The average four year-old child asks over four hundred questions a day
· Prosopagnosia refers to the inability to identify people by their faces. In severe cased prosopagnosia a person may not be able to identify themselves in a mirror
· On
· An adult sheep can eat between 1 to 4 kg of food per day
· In 1888,
· Blood is such a good stain that Native Americans used it for paint
· In 1876, the first microphone was invented by Emile Berliner.
· "I am." is the second shortest complete sentence in the English language
· On average, a person will spend about five years eating during their lifetime
· Each king in a deck of playing cards represents a great king from history. Spades - King David, Clubs - Alexander the Great, Hearts - Charlemagne, Diamonds - Julius Caesar
· Many cancer patients that are treated with chemotherapy lose their hair. For some when the hair grows back, it can grow back a different colour, or be curly or straight
· A volcano has enough power to shoot ash as high as 50 km into the atmosphere
· The longest hiccups on record was by an American pig farmer whose hiccups persisted from 1922 to 1987
· Coupons were introduced in 1894 when Asa Candler bought the Coca-Cola formula for $2,300 and gave people coupons that he had written out to receive a free glass of coke
· Panthers are known as black leopards, as they are the same species of leopard. If looked at closely, black spots can be seen on a panther
· Approximately 25% of all scald burns to children are from hot tap water and is associated with more deaths than with any other liquid
· In
· Tomatoes and cucumbers are fruits
· In the
· Cattle can produce up to 180 litres of saliva in one day
· Dolphins hear by having sound waves transmit through their skull to their inner ear region
· Teflon was accidently discovered by scientist Dr. Roy Plunkett while he was conducting a coolant gas experiment in 1938
· The risk of cardiovascular disease is twice as high in women that snore regularly compared to women who do not snore. updated
· Close to 80% of people who watch the Super Bowl on television, only do so to view the commercials
· The first theatre to show motion pictures was the Nickelodeon on
· The White House has a movie theater, swimming pool, bowling lane, jogging track, and a tennis court
· About two hundred years before the birth of Christ, the Druids used mistletoe to celebrate that winter was approaching
· Cats have over one hundred vocal sounds, dogs only have about ten
· A butterfly can see the colors red, green, and yellow
· In the game of Monopoly, the most landed on properties are B&O Railroad,
· The airplane Buddy Holly died in was the "American Pie." (Thus the nameof the Don McLean song.)
· Lions cannot roar until they reach the age of two.
· A baby kangaroo is called a joey
·
· There were 43,687 toilet related accidents in the
· In
· Ringo Starr appeared in a Japanese advertisement for apple sauce. Ironically his name means "apple sauce" in Japanese
· The average
· There is cyanide in apple pips
· True spiders always have organs for spinning silk known as spinnerets
·